< Previouselasticity can be the result of both IR treatment and skin stimulation associated with the implementation of stabilized HA, as well as the interaction of both of these factors. This is intriguing when examining potential risks linked to prolonged residence of an external entity, such as a HA-based filler implant, which may result in the formation of granulomas and other immunological responses. Zerbinati et al. [16] demonstrated that HA cross-linked with PEG has the ability to modulate polymorphonuclear leukocyte (PMN) functions, resulting in anti-inflammatory effects, and carries a very low risk of immune-mediated adverse effects. The unique safety, inflammatory, and immunological response outcomes of PEGylated filler monotherapy are especially notable, and when paired with IR technology, they are compatible with prior data on PEG’s immunomodulatory capabilities. [17]. The combination of PEGylated HA filler, which gives great integration, safety profile and tolerability, with IR device can optimize and boost results not only because it is very well to- lerated, but also effective [16, 17]. To sum up, the properties of PEGylated HA fillers affect the unique behaviour in tissu- es, and biointegration, which, combined with understanding, learning about anatomy and choosing the right application plane, as well as right product from the portfolio, may bring very unusual results. Looking at the progress of aesthetic medicine, its future is surely the intelligent mixing of multiple technologies to get the best possible outcomes, as in the preceding example. Be- fore beginning any surgery, every professional must descri- be the whole process, its reasons, and confront it with the pa- tient’s expectations. Collaborative efforts among specialists, after thorough consultations, together with increased utilisa- tion of technological devices and individual commitment to personal discipline via the use of cosmeceuticals, might yield very favourable outcomes by avoiding the need for more invasive procedures, such as surgical interventions. Due to the fact that the examined group was small and there are few scientific reports in this area, further research is recommen- ded, but even these preliminary results are optimistic. REFERENCES / LITERATURA 1 . Zhang S, Duan E. Fighting against Skin Aging: The Way from Bench to Bedside. Cell Transplant. 2018;27(5):729-738. https://doi.org/10.1177/0963689717725755 2 . Mehta-Ambalal SR. Neocollagenesis and Neoelastinogenesis: From the Laboratory to the Clinic. J Cutan Aesthet Surg. 2016;9(3):145-151. https://doi.org/10.4103/0974-2077.191645 3 . Sadick N. Tissue Tightening Technologies: Fact or Fiction. Aesthetic Sur- gery Journal. 2008;28(2):180-188. 4 . Bunin LS, Carniol PJ. Cervical facial skin tightening with an infrared de- vice. Facial Plastic Surgery Clinics of North America. 2007;15(2):179-184. 5 . Yu CS, Yeung CK, Shek SY, et al. Combined infrared light and bipo- lar radiofrequency for skin tightening in Asians. Lasers Surg Med. 2007;39(6):471-475. https://doi.org/10.1002/lsm.20515 6 . Woolery-Lloyd H, Kammer JN. Skin tightening. Curr Probl Dermatol. 2011;42:147-152. https://doi.org/10.1159/000328284 7 . Mehta-Ambalal SR. Neocollagenesis and Neoelastinogenesis: From the Laboratory to the Clinic. Journal of cutaneous and aesthetic surgery. 2016;9(3):145-151. https://doi.org/10.4103/0974-2077.191645 8 . Flynn T, Sarazin D, Bezzola A, et al. Etude histologique comparative d’in- jection intradermique de gels d’hyaluronane mono e biphasique. J Med Esth Et Chir Derm. 2011;38:219-224. 9 . Roberts MJ, Bentley MD, Harris JM. Chemistry for peptide and protein PEGylation. Adv Drug Deliv Rev. 2002;54:459-476. 10 . Park YD, Tirelli N, Hubbell JA. Photopolymerized hyaluronic acid-based hydrogels and interpenetrating networks. Biomaterials. 2003;24:893-900. 11 . Jin R, Moreira Teixeira LS, Krouwels A, et al. Synthesis and characteri- zation of hyaluronic acid-poly(ethylene glycol) hydrogels via Michael addition: An injectable biomaterial for cartilage repair. Acta Biomater. 2010;6:1968-1977. 12 . Pasut G. Polymers for Protein Conjugation. Polymers. 2014;6:160-178. 13 . Zerbinati N, D‘Este E, Farina A, et al. Morphological evidences following pegylated filler treatment in human skin. J Biol Regul Homeost Agents. 2017;31(2 Suppl. 2):79-85. 14 . Zerbinati N, Rauso R, Gonzalez P, et al. In vitro evaluation of collagen production on human fibroblasts treated with hyaluronic acid peg cross-linked with micromolecules of calcium hydroxyapatite in low concentration. J Biol Regul Homeost Agents. 2017;31(2 Suppl. 2):87-90. 15 . Martina V, Gallo A, Tarantino E, et al. Viscoelastic properties and ther- modynamic balance improvement of a hyaluronic acid hydrogel en- riched with proline and glycine. J Biol Regul Homeost Agents. 2019;33(6): 1955-1959. https://doi.org/10.23812/19-252-L 16 . Marino F, Cosentino M, Legnaro M, et al. Immune profile of hyalu- ronic acid hydrogel polyethylene glycol crosslinked: An in vitro eva- luation in human polymorphonuclear leukocytes. Dermatol Ther. 2020;33(3):e13388. 17 . Kubik P, Jankau J, Rauso R, et al. HA PEGylated Filler in Association with an Infrared Energy Device for the Treatment of Facial Skin Aging: 150 Day Follow-Up Data Report. Pharmaceuticals. 2022;15(11):1355. https://doi.org/10.3390/ph15111355 otrzymano / received: 14.06.2023 | poprawiono / corrected: 28.06.2023 | zaakceptowano / accepted: 03.07.2023 6 / 2023 Kosmetologia Estetyczna 148 Artykuł ukazał się w „Aesthetic Cosmetology and Medicine” Nelasticity can be the result of both IR treatment and skin stimulation associated with the implementation of stabilized HA, as well as the interaction of both of these factors. This is intriguing when examining potential risks linked to prolonged residence of an external entity, such as a HA-based filler implant, which may result in the formation of granulomas and other immunological responses. Zerbinati et al. [16] demonstrated that HA cross-linked with PEG has the ability to modulate polymorphonuclear leukocyte (PMN) functions, resulting in anti-inflammatory effects, and carries a very low risk of immune-mediated adverse effects. The unique safety, inflammatory, and immunological response outcomes of PEGylated filler monotherapy are especially notable, and when paired with IR technology, they are compatible with prior data on PEG’s immunomodulatory capabilities. [17]. The combination of PEGylated HA filler, which gives great integration, safety profile and tolerability, with IR device can optimize and boost results not only because it is very well to- lerated, but also effective [16, 17]. To sum up, the properties of PEGylated HA fillers affect the unique behaviour in tissu- es, and biointegration, which, combined with understanding, learning about anatomy and choosing the right application plane, as well as right product from the portfolio, may bring very unusual results. Looking at the progress of aesthetic medicine, its future is surely the intelligent mixing of multiple technologies to get the best possible outcomes, as in the preceding example. Be- fore beginning any surgery, every professional must descri- be the whole process, its reasons, and confront it with the pa- tient’s expectations. Collaborative efforts among specialists, after thorough consultations, together with increased utilisa- tion of technological devices and individual commitment to personal discipline via the use of cosmeceuticals, might yield very favourable outcomes by avoiding the need for more invasive procedures, such as surgical interventions. Due to the fact that the examined group was small and there are few scientific reports in this area, further research is recommen- ded, but even these preliminary results are optimistic. REFERENCES / LITERATURA 1 . Zhang S, Duan E. Fighting against Skin Aging: The Way from Bench to Bedside. Cell Transplant. 2018;27(5):729-738. https://doi.org/10.1177/0963689717725755 2 . Mehta-Ambalal SR. Neocollagenesis and Neoelastinogenesis: From the Laboratory to the Clinic. J Cutan Aesthet Surg. 2016;9(3):145-151. https://doi.org/10.4103/0974-2077.191645 3 . Sadick N. Tissue Tightening Technologies: Fact or Fiction. Aesthetic Sur- gery Journal. 2008;28(2):180-188. 4 . Bunin LS, Carniol PJ. Cervical facial skin tightening with an infrared de- vice. Facial Plastic Surgery Clinics of North America. 2007;15(2):179-184. 5 . Yu CS, Yeung CK, Shek SY, et al. Combined infrared light and bipo- lar radiofrequency for skin tightening in Asians. Lasers Surg Med. 2007;39(6):471-475. https://doi.org/10.1002/lsm.20515 6 . Woolery-Lloyd H, Kammer JN. Skin tightening. Curr Probl Dermatol. 2011;42:147-152. https://doi.org/10.1159/000328284 7 . Mehta-Ambalal SR. Neocollagenesis and Neoelastinogenesis: From the Laboratory to the Clinic. Journal of cutaneous and aesthetic surgery. 2016;9(3):145-151. https://doi.org/10.4103/0974-2077.191645 8 . Flynn T, Sarazin D, Bezzola A, et al. Etude histologique comparative d’in- jection intradermique de gels d’hyaluronane mono e biphasique. J Med Esth Et Chir Derm. 2011;38:219-224. 9 . Roberts MJ, Bentley MD, Harris JM. Chemistry for peptide and protein PEGylation. Adv Drug Deliv Rev. 2002;54:459-476. 10 . Park YD, Tirelli N, Hubbell JA. Photopolymerized hyaluronic acid-based hydrogels and interpenetrating networks. Biomaterials. 2003;24:893-900. 11 . Jin R, Moreira Teixeira LS, Krouwels A, et al. Synthesis and characteri- zation of hyaluronic acid-poly(ethylene glycol) hydrogels via Michael addition: An injectable biomaterial for cartilage repair. Acta Biomater. 2010;6:1968-1977. 12 . Pasut G. Polymers for Protein Conjugation. Polymers. 2014;6:160-178. 13 . Zerbinati N, D‘Este E, Farina A, et al. Morphological evidences following pegylated filler treatment in human skin. J Biol Regul Homeost Agents. 2017;31(2 Suppl. 2):79-85. 14 . Zerbinati N, Rauso R, Gonzalez P, et al. In vitro evaluation of collagen production on human fibroblasts treated with hyaluronic acid peg cross-linked with micromolecules of calcium hydroxyapatite in low concentration. J Biol Regul Homeost Agents. 2017;31(2 Suppl. 2):87-90. 15 . Martina V, Gallo A, Tarantino E, et al. Viscoelastic properties and ther- modynamic balance improvement of a hyaluronic acid hydrogel en- riched with proline and glycine. J Biol Regul Homeost Agents. 2019;33(6): 1955-1959. https://doi.org/10.23812/19-252-L 16 . Marino F, Cosentino M, Legnaro M, et al. Immune profile of hyalu- ronic acid hydrogel polyethylene glycol crosslinked: An in vitro eva- luation in human polymorphonuclear leukocytes. Dermatol Ther. 2020;33(3):e13388. 17 . Kubik P, Jankau J, Rauso R, et al. HA PEGylated Filler in Association with an Infrared Energy Device for the Treatment of Facial Skin Aging: 150 Day Follow-Up Data Report. Pharmaceuticals. 2022;15(11):1355. https://doi.org/10.3390/ph15111355 otrzymano / received: 14.06.2023 | poprawiono / corrected: 28.06.2023 | zaakceptowano / accepted: 03.07.2023SIŁA LODOWCA W TWOJEJ PIELĘGNACJI ROZŚWIETLENIE I ANTI-AGING NATURALNE WŁOSKIE KOSMETYKI Wyłączny dystrybutor w Polsce | www.itpsa.pl | tel. +48 722 008 002 facebook/VagheggiPolandByITPinstagram/Vagheggi_PolandNext >